HEPES ULTRA PC™ Multifunctional Additive

  • Chemical Name: 4-(2-hydroxyethyl)-1-piperazineethanesulfonic Acid INCI Name: Hydroxyethylpiperazine Ethane Sulfonic Acid
  • CAS No.: 7365-45-9
  • EINECS No.: 230-907-9
  • Common Synonyms hydroxyethyl piperazineethanesulfonic acid, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid

HEPES ULTRA PC™ is a multifunctional additive for personal care applications. HEPES ULTRA PC is a zwitterionic buffer and one of Good’s 12 buffers. HEPES ULTRA PC is an effective pH stabilizer with a useful pH buffering range from 6.8 to 8.2. HEPES ULTRA PC has good water solubility, heat resistance, low cell membrane permeability, and high stability against oxidation-reduction reactions and UV light. HEPES ULTRA PC can be used in combination with other ingredients to support the quality and performance of skincare and cosmetics products. In addition, HEPES ULTRA PC can promote the absorption of effective ingredients in skin care.

Uses and Applications

HEPES ULTRA PC can be used in multiple personal care and color cosmetics applications, including, but not limited to:

  • Skin creams and lotions
  • Toners
  • Serums
  • Cleansers
  • Sunscreens

Typical Properties*

  • Appearance White Powder
  • Purity wt% (min) ≧ 99
  • Secondary amines (wt%) <0.5
  • Nitrosamine content (ppb) <50
  • Molecular weight (g) 238.3
  • Water, wt% 0.5
  • pKa@ 25°C 3 and. 7.45
  • Solubility in water, 20°CMiscible

*Values shown are typical properties and are not to be considered product specifications. Test methods available upon request.

Product Benefits

  • Can be used in combination with other ingredients to support the quality and performance of skincare and cosmetics products.
  • Has good water solubility, heat resistance, low cell membrane impermeability, and high stability against oxidation-reduction reactions and UV light.
  • HEPES buffer has been referenced in literature to stabilize functional acidic ingredients such as glycolic acid, AHAs (alpha hydroxy acids) and BHAs (beta-hydroxy acids) in skin brightening or depigmentation formulations.

Compliance and Regulatory Status

HEPES ULTRA PC™ is compliant with the industry’s most stringent standards and regulations worldwide, including:

U.S. Food, Drug and Cosmetic Act

European Union Regulation No. 1223/2009

ASEAN 2008 Cosmetic Directive (annex updated March 2013)

Brazil ANVISA Mercosur Resolution on Personal Hygiene Products and Cosmetics

Mexico: not included in the List of Prohibited and Restricted Substances in Perfumes and Cosmetics

HEPES ULTRA PC™ Multifunctional Additive Downloads

Literature: ULTRA PC™ Amino Alcohols – Brochure
Literature: ULTRA PC™ Amino Alcohols – Formulating Fact Sheet
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